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Human CMASP-3 quantitates human CMASP-3 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CMASP-3.
MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : 3MC1, CRARF, CRARF1, MAP1, MAp44, MASP, MASP1, MASP3, PRSS5, RaRF
基因ID : (Human) 5648
基因符号 : MASP1
蛋白别名 : C4/C2 activating component of Ra-reactive factor, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, mannan-binding, mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor), Mannan-binding lectin serine protease 1, Mannose-binding lectin-associated serine protease 1, Mannose-binding protein-associated serine protease, MASP-1, Ra-reactive factor serine protease p100, RaRF, Serine protease 5
UniProt ID (Human) P48740