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Human GPVI quantitates human GPVI in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human GPVI.
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : BDPLT11, GPIV, GPVI
基因ID : (Human) 51206
基因符号 : GP6
蛋白别名 : glycoprotein 6, platelet collagen receptor
UniProt ID (Human) Q9HCN6