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Invitrogen
Human ST2 (IL-33R) ELISA Kit
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产品规格
检测灵敏度
4.6 pg/mL
测定范围
4.7-300 pg/mL
检测样本类型/体积
{Cell lysate=10 µL, Plasma=10 µL, Serum=10 µL}
手工操作时间
1 hr 20 min
总时间
3 hr 10 min
均相（无需洗涤）
No
批间差异
3.5%
批内差异
4.5%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
2-8°C
蛋白名称
ST2
Target sub-specificity
Soluble
蛋白家族
Cytokine Receptor
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
The Human ST2 (IL-33R) ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of human ST2 (IL-33R).
靶标信息
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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生物信息学
基因别名 : DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
基因ID : (Human) 9173
基因符号 : IL1RL1
蛋白别名 : DER4, Fit-1, IL-1 R4, IL1R4, IL-1R4, IL-1RL1, IL-33R, Ly84, ST2, ST2L, ST2V, suppression of tumorigenicity 2, T1, Interleukin1 receptor like 1, sIL 33R, soluble IL 33 Receptor, soluble IL 33R, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-related protein, soluble protein receptor, suppressor of tumorigenicity 2, unnamed protein product
UniProt ID (Human) Q01638
