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Human TGF beta-3 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human TGF beta 3 in cell culture supernatants and serum samples.
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : ARVD, ARVD1, LDS5, RNHF, TGF-beta3, TGFB3
基因ID : (Human) 7043
基因符号 : TGFB3
蛋白别名 : FLJ16571, H-TGF-b-3, tgf beta 3, Transforming growth factor, prepro-transforming growth factor beta-3, TGF-beta-3, Transforming growth factor beta-3 proprotein, transforming growth factor, beta 3
UniProt ID (Human) P10600