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Bioprocess Filtration Resources

A centralized hub for filtration and purification resources

Filtration decisions shape yield, impurity profiles, and downstream process (DSP) performance. The bioprocess filtration hub brings together technical resources to support scalable downstream development and informed decision-making across bioprocessing stages.

Explore the latest bioprocess filtration education resources

Single-stage clarification with chromatographic capture

Applying chromatographic principles to cell clarification can consolidate multi-step harvest operations into a single stage. This approach can affect loading capacity, impurity clearance, operational complexity, and process economics in recombinant protein production.

Can drug platforms keep up with complex molecules?

As molecular complexity increases, traditional manufacturing platforms face emerging scalability and efficiency constraints. Advances in separation science are being reconsidered to support multiple modalities while  maintaining efficient and scalable downstream operations.

Single-use chromatographic clarification of CHO cell harvest

Single-stage chromatographic clarification using Harvest RC Chromatographic Clarifier is an alternative to three-step filtration trains for Chinese hamster ovary (CHO) cell harvest. Through process compression, this approach has been shown to reduce process cost by 17%–30%.

Explore the full bioprocess filtration resource library

Find technical documents, articles, videos, and webinars aligned to specific filtration and purification challenges across downstream bioprocessing workflows.

Application notes

Articles

Brochures and product information sheets

Infographics

Papers

Technical notes

Videos

Note: The content in these videos may include Solventum or 3M branding that will transition to Thermo Fisher Scientific branding.
 

White papers

Application note

Brochure

Data sheet

Papers

Technical notes

Videos

Note: The content in these videos may include Solventum or 3M branding that will transition to Thermo Fisher Scientific branding.
 

Webinars

Brochures

Videos

Note: The content in these videos may include Solventum or 3M branding that will transition to Thermo Fisher Scientific branding.
 

Related areas of interest

Filtration decisions rarely occur in isolation. Upstream variability, downstream purification demands, and analytical strategy impact clarification performance. These resource areas offer greater workflow context to support integrated bioprocess design.

Bioprocess insights

Access resources that examine upstream and downstream perspectives relevant to process design, scale-up, and manufacturing strategy. Filtration decisions fit within the overall bioprocess and require integrated workflow considerations.

Chromatography

Explore chromatography-focused resources that touch on purification steps that follow or interface with clarified feeds. Understanding this interaction helps define impurity reduction strategies, yield trade-offs, and downstream consistency requirements.

Pharmaceutical analytics

Access analytical resources used to evaluate clarification performance, monitor process consistency, and characterize impurities. Analytical resources inform decisions around filtration design, performance, and risk assessment throughout development.

Explore the School of Purification

Gain practical insights into filtration, purification strategy, technology transfer, and emerging therapeutic applications.

 

Whether you are strengthening foundational knowledge or evaluating approaches for process development and manufacturing, the School of Purification supports ongoing learning across bioprocessing workflows.

Explore filtration solutions for your workflow

Intended use of the products mentioned on this page vary. For specific intended use statements, please refer to the Instructions for Use for the product.