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Thank you for your interest in our nucleic acid therapeutics portfolio. One of our technical specialists will be in touch with you shortly.

Please visit these sites for more information about our comprehensive end-to-end nucleic acid therapeutics development and manufacturing portfolio:

Whether you have limited cloning experience or simply want to save time, the GeneArt Gene Synthesis service helps you move your ideas from the planning stage to the laboratory more quickly. Benefit from our experience in successfully producing over 180,000 constructs for customers as diverse as large pharmaceutical companies, biotechnology start-ups, and basic research institutions.

With a portfolio of solutions that span discovery through large-scale commercial production, we bring process intensification across your upstream and downstream workflows, without compromising on quality. And to stay ahead of future bioprocessing needs, we are focused on working with customers and utilizing our unique capabilities, like open architecture engineering and customization, to provide the right solutions to achieve optimal bioprocessing outcomes. That’s our commitment to you and it’s what we call Bioprocessing by Design.

To meet your downstream processing needs, we offer a variety of commercialized resins for affinity, ion exchange (IEX), and hydrophobic interaction chromatography (HIC) applications. From large-scale bioprocess resins and small-scale purification solutions to pre-packed columns and analytical tools for characterization, we have you covered. The Thermo Scientific CaptureSelect and POROS resin technologies address today’s challenges in the purification workflow.

Accelerate mRNA vaccine and therapeutic production from preclinical development to commercialization with the portfolio of Thermo Scientific TheraPure restriction enzymes, in vitro transcription enzymes, nucleotides, and capping solutions that are designed to meet critical process, scale, quality, and regulatory needs. Partner with us to help accelerate the commercialization of your mRNA vaccines and therapeutics.

The rapid evolution of mRNA-based vaccines has led to a need for scalable purification solutions which can be used in commercial manufacturing. POROS Oligo (dT)25 affinity resin was developed to address the selectivity and capacity requirements for large-scale purification of mRNA constructs from in vitro transcription (IVT) processes.

Because mRNA is transient in the body, synthetic mRNA products require modifications to protect the product from natural degradation. To ensure safety and efficacy regulatory agencies demand in-depth analytical characterization and criteria defined for purity/impurity monitoring (Critical Quality Attributes or CQAs). Impurities are identified during characterization, with acceptable levels defined, and monitored throughout manufacture and lot release.

Thermo Fisher Scientific utilize leading instrumentation, consumables, and software to provide optimized mRNA characterization and impurity analysis.

The emergence of mRNA therapeutics including the development of new vaccines and gene therapies has created a market constraint on access to critical raw materials and scientific and technical expertise. Thermo Fisher Scientific knows nucleic acids and pharmaceutical services, and has worked to integrate our capabilities across the operational value chain to enable the development and commercialization of mRNA therapeutics. Our global network of sites with mRNA capabilities includes cGMP manufacture, formulation with liquid nanoparticle (LNP), sterile fill and finish, as well as logistics and supply chain networks. We are well-suited to support complex and unique cGMP mRNA manufacturing needs and scale-up.

Synthesize your high-quality DNA and RNA oligonucleotides with the confidence from partnering with a proven global leader in nucleic acid chemistry. With 40 years of engineered nucleic acid manufacturing experience, phosphoramidites are a unification of our expertise in protection chemistries, modifications, manufacturing scale-up and innovative purification strategies. Thermo Scientific TheraPure phosphoramidites are designed for oligonucleotide manufacturers requiring highly defined impurity profiles and strictly controlled processes.