Bio/Pharma Analytical Solutions

Emerging applications continue to shape the future of pharmaceutical analytical workflows, from novel therapeutic classes like GLP-1s to heightened regulatory demands around contaminants such as PFAS. This section highlights the trends redefining how scientists are improving speed, precision, and compliance across the drug development lifecycle.

Therapeutic peptides, a class of pharmaceutical products made up of amino acids, have gained significant attention for their potential in treating a variety of diseases. With over 100 approved peptide medications worldwide, including the best-selling semaglutide for type 2 diabetes and weight management, the development of these drugs is rapidly expanding. However, challenges in production, including the identification and control of peptide-related impurities, have driven advancements in analytical technologies like Liquid Chromatography coupled with HRAM mass spectrometry for improved quality control.

PFAS (per and polyfluoroalkyl substances) play a complex role in pharmaceutical packaging. Valued for durability and resistance, they are commonly found in coatings, seals, and container linings. However, their persistence in the environment and rising regulatory scrutiny have put them in the spotlight. This section shares industry insights on PFAS in pharma packaging, covering detection, compliance, and safer alternatives, helping manufacturers and suppliers stay ahead of evolving standards while protecting product quality and patient safety.

Bioanalysis is crucial for oligonucleotide therapeutic drug development as it enables the precise measurement of drug concentrations and their metabolites in biological matrices. This is essential for understanding the pharmacokinetics, pharmacodynamics, and safety profiles of these therapeutics. Accurate bioanalytical methods ensure that the drug's absorption, distribution, metabolism, and excretion (ADME) properties are well-characterized, facilitating dose optimization and efficacy assessment. Additionally, bioanalysis helps in monitoring potential off-target effects and immunogenic responses, thereby ensuring the overall safety and effectiveness of oligonucleotide-based therapies.

Thermo Fisher Scientific provides technology innovations to support biopharmaceutical companies of all sizes–our workflows are leveraged by major manufacturers like Pfizer and Merck, as well as innovative research organizations like LifeArc, Bio-Techne Corporation, and NIBRT.

“Many of our academic collaborators have been using Orbitrap technology to aid their research for years, now it is great for us to apply it to both our biopharmaceutical and small molecule programs to accelerate their progression,” said Dr. David Tickle, Senior Principle Scientist, LifeArc.

Thermo Fisher Scientific offers a superior portfolio of fit-for-purpose solutions to meet your drug development and drug release needs with compliance in mind. Our solutions include cutting-edge mass spectrometry, reliable LC, GC, and IC separation, as well as high-throughput instruments designed for routine analysis.

Behind every instrument is SMART software designed to make life easy for you, whilst maintaining compliance to answer your most difficult analytical questions faster for a broad range of pharmaceutical applications.