Our base systems support a range of pressures, flow rates, column dimensions, and detector options to meet your application and performance needs.

Vanquish Core HPLC Systems
Vanquish Flex UHPLC Systems
Vanquish Horizon UHPLC Systems
Vanquish Neo UHPLC System
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Description
A dependable workhorse for your high-volume QC analysisRun HPLC and UHPLC analyses on a single systemRun smaller particles and column dimensions with confidenceDelivers robust separations 24/7 to support your high-sensitivity LC-MS workflows
Pump options
Binary, quaternary, dual & isocraticBinary, quaternary & dualBinaryBinary
Maximum system pressure
700 bar1000 bar1500 bar1500 bar
Flow range
0.001–10 mL/min0.001–8 mL/min0.001–5 mL/min1 nL/min–100 μL/min
Column particle size
3–5 µm1.5–3 µm< 3 µm≤ 3 µm
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Application-specific systems

Our application-specific instruments can help you maximize productivity, sample knowledge and purity, or optimize methods.

Vanquish Duo HPLC & UHPLC Systems
Vanquish Online 2D-LC Systems
Vanquish Analytical Purification LC Systems
Vanquish Method Development System
System feature
Run two analyses, simultaneously, on one instrumentImprove analysis of complex samples or simplify separation of poorly resolved analytesHigh-performance fractionation capabilities to deliver you ultra-pure productsAccelerate and optimize your method by testing different buffers mixtures across six columns
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Featuring a handful of new enhancements with replaceable parts to help increase your return on investment and support your sustainability goals. Our Vanquish LC Systems are now easier to use, more reliable, and include torque-controlled fingertight fittings as standard.

Easier to use

  • Tool-free torque-controlled fitting technology helps you lock in confident fluidic connections
  • Full suite of built-in tools to ease method transfer and support cross-lab data consistency
  • Perform system prep work at instrument with enhanced Vanquish User Interface

Faster workflows

  • Supports a wide pressure range to accommodate using columns with smaller dimensions
  • Dual-channel instruments double your throughput without taking up more bench space
  • Automatic vessel bottom recognition helps you get more from each sample
  • Optional auto-sampler extension to maximize your daily sample capacity

More sustainable parts

  • Platinum ACT 2.0 Ecolabel instrument rating supports sustainable operations
  • Manufactured in facilities fully powered by renewable energy
  • More sustainable packing for Viper TQ UHPLC Fittings
  • Replaceable capillaries for column active pre-heaters

How to Make Your HPLC Workflows Smarter, Faster & Greener

What our customers love
Using the new fluidic connections with Viper TQ UHPLC Fitting design on our Vanquish LC systems has been a great experience. The robust and tight connections provide a high level of reliability, and the capillaries are easier to use compared to other solutions. The tactile feedback ensures that the fittings are properly secured, regardless of the columns used. I also value the active pre-heater TQ design with its replaceable outlet capillaries, which improves ecological efficiency while providing performance and consistency in my analyses. The addition of the new eluent filters is another great benefit, making the overall system even more user-friendly.
— Lydia D. | Pharma
I love my Vanquish HPLC so much because its performance is so reliable. During the pandemic, we didn't get a chance to work on it, and it was turned off for over a year. But after we returned to the lab, we did quick routine maintenance and injected some QC samples. The retention times of the standards aligned SO WELL with previous QCs. I was absolutely in awe of the reproducibility. I would definitely recommend Vanquish to my colleagues.
— Harong L. | Academia
My Vanquish UHPLC, named Cynthia, has been a fantastic addition to my lab space. Fast run times, robust methodology, and the ease of use for Chromeleon makes Cynthia a vital part of my lab team!
— Bjorn L. | Industry
We performed a method translation from a dated HPLC method to UHPLC on the Vanquish. The new method allows this test to be performed within one shift instead of across multiple shifts/personnel.
— Nicholas G. | Pharma

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Style Sheet for Global Design System