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Invitrogen
Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein
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产品信息
A42529
产品规格
种属
Human
Expression System
HEK293 cells
氨基酸序列
Human FCGR2A, amino acids Met1-Ile218 (Accession # P12318-1) with natural variant H167R substitution with a C-terminal His-tag
标签
His-tag
分子量
22 kDa
分类
Recombinant
类型
Protein
纯度
>95 % as determined by SDS-PAGE. >90 % as determined by SEC-HPLC
内毒素浓度
<1.0 EU/µg
活性
1.Loaded Rituximab (IgG1) on ProA Biosensor, can bind Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein with an affinity constant of 2.3 µM as determined in a BLI assay (Sartorius Octet Red384) (Routinely tested).
2.Loaded Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein on His1K Biosensor, can bind Bevacizumab (IgG1) with an affinity constant of 0.65 µM as determined in a BLI assay (Sartorius Octet Red384) (QC tested).
3.Captured Bevacizumab (IgG1) on proA Chip can bind Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein with an affinity constant of 0.79 µM as determined in an SPR assay (Biacore T200) (Routinely tested).
4.The purity of Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein is more than 95% and the molecular weight of this protein is around 23-32 kDa verified by SEC-MALS.
2.Loaded Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein on His1K Biosensor, can bind Bevacizumab (IgG1) with an affinity constant of 0.65 µM as determined in a BLI assay (Sartorius Octet Red384) (QC tested).
3.Captured Bevacizumab (IgG1) on proA Chip can bind Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein with an affinity constant of 0.79 µM as determined in an SPR assay (Biacore T200) (Routinely tested).
4.The purity of Human Fc gamma RIIA (CD32a) (167 Arg/His) His-tag Recombinant Protein is more than 95% and the molecular weight of this protein is around 23-32 kDa verified by SEC-MALS.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient
产品详细信息
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
靶标信息
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD32; CDw32; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor IIa; Fc-gamma RII-a; Fc-gamma-RIIa; fcRII-a; IgG Fc receptor II-a; Immunoglobulin G Fc receptor II; Low affinity immunoglobulin gamma Fc region receptor II-a
基因别名: CD32; CD32A; CDw32; FCG2; FcGR; FCGR2; FCGR2A; FCGR2A1; IGFR2
UniProt ID: (Human) P12318
Entrez Gene ID: (Human) 2212
