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Invitrogen
Human G-CSF Recombinant Protein, eBioscience™
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产品信息
BMS322
产品规格
种属
Human
Expression System
E. coli
分子量
18.8 kDa
分类
Recombinant
类型
Protein
纯度
>97%
偶联物
形式
Lyophilized
纯化类型
purified
保存液
10mM sodium acetate, pH 4.0
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Description: Granulocyte colony stimulating factor (G-CSF) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukaemia cells.
The protein is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. The protein is highly conserved among species. G-CSF has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors and neutrophilic granulocytes as well as certain carcinoma cell lines. Human G-CSF is a 18.8 kDa protein containing 175 amino acid residues. A soluble isoform of the G-CSF receptor has been described. Clinical use of G-CSF has been approved for several therapeutical applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet's syndrome and Aids.
G-CSF has further been shown to be a marker protein for different carcinomas such as bladder cancer.
Purity: >97%.
Molecular Weight: 18.8 kDa.
靶标信息
G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. G-CSF is highly conserved among species and has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors, neutrophilic granulocytes and certain carcinoma cell lines. Clinical use of G-CSF has been approved for several therapeutic applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet's syndrome and AIDS. Further, G-CSF has been shown to be a marker protein for different carcinomas such as bladder cancer and dysfunction of the protein has been linked to Kostmann Syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: colony stimulating factor 3 (granulocyte); CSF 3; filgrastim; G-CSF; Granulocyte colony-stimulating factor; granulocyte-colony stimulating factor; gsf3; lenograstim; MGC45931; Pluripoietin; RP23-395E10.4
基因别名: C17orf33; CSF3; CSF3OS; GCSF
UniProt ID: (Human) P09919
Entrez Gene ID: (Human) 1440
