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Invitrogen
Human PON1 Recombinant Protein
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Product Details
RP-75678
Product Specifications
Class
Recombinant
Type
Protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-75678 contains purified recombinant human Paraoxonase 1 Mammalian Cell Lysate protein expressed in CHO-K1 cells with an carboxy-terminal hexahistidine tag.
RP-75678 may be used as a positive control in many immunological assays. Paraoxonase-1 catalyses the cleavage of phenyl acetate (4mM) in 20mM TrisHCl buffer, pH 8, containing 1mM calcium chloride resulting in phenol formation. The rate of formation of phenol is measured by monitoring the increase in absorbance at 270 nm at 25 C. One unit of arylesterase activity is equal to 1uM of phenol formed per minute. The activity is expressed in kU/L, based on the extinction coefficient of phenol of 1310 1/M cm at 270 nm, pH 8, and 25 C.
The total acitivity of RP-75678 is 13.87 U/mL.
RP-75678 has a molecular weight of ~42.9 kDa.
Target Information
The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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