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5HT7 R Polyclonal Antibody
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5HT7 R Antibody (OSS00205W-100UL) in IHC (P)
IHC-P on paraffin sections of rat brain. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromogen fro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
OSS00205W-100UL
产品规格
种属反应
Guinea pig,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from human 5HT7 R conjugated to blue carrier protein was used as the antigen
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat, mouse and guinea pig.
Specificity of this antibody: 5HT7R receptor.
靶标信息
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5-HT-7; 5-HT-X; 5-HT7; 5-HT7 receptor; 5-HT7b receptor; G protein coupled receptor; 5-HT7c receptor; G protein coupled receptor; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine7 receptor; 5HT7 Receptor; GPRFO; high affinity serotonin receptor (5HT7); HT7; HTR7B; G-protein coupled receptor; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; serotonin receptor 7; unnamed protein product
基因别名: 5-HT-X; 5-HT7; 5Ht7
UniProt ID: (Human) P34969, (Rat) P32305, (Guinea pig) P50407, (Mouse) P32304
Entrez Gene ID: (Human) 3363, (Rat) 65032, (Guinea pig) 100135549, (Mouse) 15566
smooth muscle contraction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating serotonin receptor signaling pathway
chemical synaptic transmission
circadian rhythm
blood circulation
vasoconstriction
G protein-coupled serotonin receptor signaling pathway
serotonin receptor signaling pathway
memory
positive regulation of neuron projection development
negative regulation of serotonin secretion
urinary bladder smooth muscle contraction
behavioral response to pain
detection of mechanical stimulus involved in sensory perception of pain
response to corticosterone
response to electrical stimulus
long-term synaptic potentiation
regulation of vein smooth muscle contraction
dopaminergic neuron differentiation
presynaptic modulation of chemical synaptic transmission
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
