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Invitrogen
ACAP2 Polyclonal Antibody
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产品信息
PA5-88364
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 50-160 of human ACAP2 (NP_0364193)
偶联物
形式
Liquid
浓度
1.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KAFCVANKQF MNGIRDLAQY SSNDAVVETS LTKFSDSLQE MINFHTILFD QTQRSIKAQL QNFVKEDLRK FKDAKKQFEK VSEEKENALV KNAQVQRNKQ HEVEEATNIL T; Positive Samples: LO2, HeLa, Jurkat, U-87MG, A-549, Mouse brain, Mouse liver; Cellular Location: Endosome membrane, Peripheral membrane protein
靶标信息
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arf GAP with coiled coil, ANK repeat and PH domains 2; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; centaurin beta2; centaurin, beta 2; Centaurin-beta-2; Cnt-b2
基因别名: 4832442G16; 9530039J15Rik; ACAP2; CENTB2; CNT-B2; KIAA0041; mKIAA0041
UniProt ID: (Human) Q15057, (Mouse) Q6ZQK5
Entrez Gene ID: (Human) 23527, (Mouse) 78618
