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Proteintech
AKR1C4 Polyclonal Antibody
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产品信息
18852-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AKR1C4 Fusion Protein Ag13444 (1-323 aa encoded by BC020744)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDPKYQRVE LNDGHFMPVL GFGTYAPPEV PRNRAVEVTK LAIEAGFRHI DSAYLYNNEE QVGLAIRSKI ADGSVKREDI FYTSKLWCTF FQPQMVQPAL ESSLKKLQLD YVDLYLLHFP MALKPGETPL PKDENGKVIF DTVDLSATWE VMEKCKDAGL AKSIGVSNFN YRQLEMILNK PGLKYKPVCN QVECHPYLNQ SKLLDFCKSK DIVLVAHSAL GTQRHKLWVD PNSPVLLEDP VLCALAKKHK RTPALIALRY QLQRGVVVLA KSYNEQRIRE NIQVFEFQLT SEDMKVLDGL NRNYRYVVMD FLMDHPDYPF SDEY (1-323 aa encoded by BC020744)
靶标信息
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; 3alpha-hydroxysteroid 3-dehydrogenase; Aldo-keto reductase family 1 member C4; CDR; Chlordecone reductase; chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4; DD-4; Dihydrodiol dehydrogenase 4; dihydrodiol dehydrogenase isozyme DD4; HAKRA; HGNC:387; MGC22581; type I 3-alpha-hydroxysteroid dehydrogenase
基因别名: 3-alpha-HSD; AKR1C4; C11; CDR; CHDR; DD-4; DD4; HAKRA
UniProt ID: (Human) P17516
Entrez Gene ID: (Human) 1109
retinal dehydrogenase activity
aldo-keto reductase (NADP) activity
electron carrier activity
bile acid transmembrane transporter activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
androsterone dehydrogenase activity
chlordecone reductase activity
oxidoreductase
reductase
metabolite interconversion enzyme
