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Product Details
PA5-96599
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
A synthetic peptide corresponding to amino acids 350-450 of human BCL6.
Conjugate
Unconjugated
形式
Liquid
浓度
2.16 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2808401
Product Specific Information
Immunogen sequence: SKNACILQAS GSPPAKSPTD PKACNWKKYK FIVLNSLNQN AKPEGPEQAE LGRLSPRAYT APPACQPPME PENLDLQSPT KLSASGEDST IPQASRLNNI V
Positive Samples: Raji, Jurkat, Mouse lung; Cellular Location: Nucleus
Target Information
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
Gene Aliases: Bcl-6; BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51
UniProt ID: (Human) P41182, (Mouse) P41183
Entrez Gene ID: (Human) 604, (Rat) 303836, (Mouse) 12053
Molecular Function:
C2H2 zinc finger transcription factor
protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
negative regulation of cell-matrix adhesion
germinal center formation
regulation of germinal center formation
negative regulation of B cell apoptotic process
transcription, DNA-templated
inflammatory response
cellular response to DNA damage stimulus
Rho protein signal transduction
spermatogenesis
negative regulation of cell proliferation
actin cytoskeleton organization
myeloid cell differentiation
B cell differentiation
negative regulation of cell growth
positive regulation of B cell proliferation
positive regulation of histone deacetylation
negative regulation of mast cell cytokine production
negative regulation of Rho protein signal transduction
type 2 immune response
regulation of cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
regulation of GTPase activity
regulation of memory T cell differentiation
negative regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of isotype switching to IgE isotypes
erythrocyte development
regulation of inflammatory response
regulation of neurogenesis
regulation of immune response
positive regulation of cellular component movement
negative regulation of cellular senescence
negative regulation of type 2 immune response
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein localization
biological_process
negative regulation of apoptotic process
negative regulation of cell differentiation
immune system process
regulation of transcription, DNA-templated
RNA polymerase II regulatory region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
metal ion binding
molecular_function
DNA binding
nucleic acid binding
Performance Guarantee
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