Invitrogen

BDNF Polyclonal Antibody

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2个已发表图片
5 篇参考文献
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

PA5-85730

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
查看4篇已发表文章 4篇已发表文章

免疫组化 (IHC)

-
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human BDNF. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.48 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2792869

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Cat (100%), Pig (100%), Chimpanzee (100%), Bovine (100%).

Positive Control: mouse brain, rat brain, BDNF-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Abrineurin; anorexia BDNF; brain derived neurothrophic factor; brain derived neurotrophic factor; Brain-derived neurotrophic factor; H-BDNF; Neurotrophic factor BDNF precursor form; neurotrophin; proBDNF

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基因别名: ANON2; BDNF; BULN2

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UniProt ID: (Human) P23560, (Rat) P23363, (Mouse) P21237

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Entrez Gene ID: (Human) 627, (Rat) 24225, (Mouse) 12064

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功能
neurotrophin TRKB receptor binding growth factor activity receptor binding protein binding neurotrophic factor
参与通路
cell-cell signaling nervous system development axon guidance synapse assembly brain-derived neurotrophic factor receptor signaling pathway positive regulation of brain-derived neurotrophic factor receptor signaling pathway negative regulation of neuron apoptotic process collateral sprouting positive regulation of collateral sprouting positive regulation of synapse assembly ureteric bud development behavioral fear response response to hypoxia chronic inflammatory response mitochondrial electron transport, NADH to ubiquinone transmembrane receptor protein tyrosine kinase signaling pathway gamma-aminobutyric acid signaling pathway negative regulation of neuroblast proliferation axon target recognition learning or memory learning circadian rhythm feeding behavior neuron recognition response to light stimulus response to light intensity response to hormone response to auditory stimulus glutamate secretion response to fluoxetine response to activity dendrite development regulation of metabolic process nerve development neuron differentiation regulation of axon extension response to nutrient levels response to food negative regulation of synaptic transmission, GABAergic positive regulation of peptidyl-serine phosphorylation response to vitamin A response to tumor necrosis factor response to potassium ion mechanoreceptor differentiation response to drug fear response negative regulation of apoptotic process regulation of neuron apoptotic process positive regulation of neuron differentiation negative regulation of striated muscle tissue development regulation of retinal cell programmed cell death regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity axon extension inner ear development cognition positive regulation of sequence-specific DNA binding transcription factor activity response to electrical stimulus response to hyperoxia excitatory postsynaptic potential inhibitory postsynaptic potential negative regulation of cell death taste bud development cellular response to tumor necrosis factor cellular response to norepinephrine stimulus response to anesthetic dendrite extension negative regulation of neuron death response to L-glutamate response to nerve growth factor cellular response to nerve growth factor stimulus neuron projection extension positive regulation of glucocorticoid receptor signaling pathway neuron projection morphogenesis cellular response to acid chemical
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