Invitrogen

BMP-2 Polyclonal Antibody

BMP-2 Antibody in Immunocytochemistry (ICC/IF)

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BMP-2 Antibody (PA5-85956) in ICC/IF

Immunocytochemical analysis of BMP-2 in MCF-7 cells using a BMP-2 Polyclonal antibody (Product # PA5-85956) as seen in green. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. DAPI was used to stain the cell nuclei (blue).

BMP-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BMP-2 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

BMP-2 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-85956

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200

免疫组织化学（多聚甲醛固定） (IHC (PFA))

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:200

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

1:100-1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide within human BMP2 aa 51-100.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 40% Glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2802757

靶标信息

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Does Chronic Pancreatitis in Growing Pigs Lead to Articular Cartilage Degradation and Alterations in Subchondral Bone?

International journal of molecular sciences

Tomaszewska E,Hułas-Stasiak M,Dobrowolski P,Świątkiewicz M,Muszyński S,Tomczyk-Warunek A,Blicharski T,Donaldson J,Arciszewski MB,Świetlicki M,Puzio I,Bonior J

Published figure using BMP-2 polyclonal antibody (Product # PA5-85956) in Immunohistochemistry

Tue Feb 06 00:00:00 UTC 2024

Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis.

World journal of orthopedics

Zhou XC,Wang DX,Zhang CY,Yang YJ,Zhao RB,Liu SY,Ni GX

Published figure using BMP-2 polyclonal antibody (Product # PA5-85956) in Immunohistochemistry

Thu Apr 18 00:00:00 UTC 2024

ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival.

The Journal of biological chemistry

Das S,Mondal A,Dey C,Chakraborty S,Bhowmik R,Karmakar S,Sengupta A

Published figure using BMP-2 polyclonal antibody (Product # PA5-85956) in Western Blot

Sat Apr 01 00:00:00 UTC 2023

ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival.

The Journal of biological chemistry

Das S,Mondal A,Dey C,Chakraborty S,Bhowmik R,Karmakar S,Sengupta A

Published figure using BMP-2 polyclonal antibody (Product # PA5-85956) in Western Blot

Sat Apr 01 00:00:00 UTC 2023

Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing.

International journal of molecular sciences

Oranger A,Zerlotin R,Buccoliero C,Sanesi L,Storlino G,Schipani E,Kozloff KM,Mori G,Colaianni G,Colucci S,Grano M

PA5-85956 was used in Immunohistochemistry to suggest that irisin can contribute to fracture repair by reducing inflammation and promoting vessel invasion, matrix degradation, and bone formation, supporting its possible role as a novel molecule for fracture treatment.

Tue Jan 17 00:00:00 UTC 2023

SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF-β1 signaling pathway.

Journal of clinical biochemistry and nutrition

Wang X,Wang M,Zhou Z,Zou X,Song G,Zhang Q,Zhou H

PA5-85956 was used in Western Blotting to evaluate the function of SMOC2 in abdominal aortic aneurysm.

Fri Sep 01 00:00:00 UTC 2023

Femoral µCT Analysis, Mechanical Testing and Immunolocalization of Bone Proteins in β-Hydroxy β-Methylbutyrate (HMB) Supplemented Spiny Mouse in a Model of Pregnancy and Lactation-Associated Osteoporosis.

Journal of clinical medicine

Tomaszewska E,Muszyński S,Donaldson J,Dobrowolski P,Chand DKP,Tomczyk-Warunek A,Hułas-Stasiak M,Puzio I,Lamorski K,Sławiński C,Jabłoński M,Blicharski T

PA5-85956 was used in Immunohistochemistry (PFA) to determine the effects of ß-hydroxy-ß-methylbutyrate supplementation during pregnancy on osteoporotic bone quality postpartum and post-lactation using spiny mice (Acomys cahirinus) as the animal models.

Wed Oct 20 00:00:00 UTC 2021

Journal of clinical medicine

Tomaszewska E,Muszyński S,Donaldson J,Dobrowolski P,Chand DKP,Tomczyk-Warunek A,Hułas-Stasiak M,Puzio I,Lamorski K,Sławiński C,Jabłoński M,Blicharski T

Wed Oct 20 00:00:00 UTC 2021

生物信息学

蛋白别名: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP-2; BMP-2A; BMPR-II; BMPRII; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; Bone morphogenetic protein 2A; H-BMP-2

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基因别名: AI467020; BDA2; Bmp-2; BMP2; BMP2A

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UniProt ID: (Human) P12643, (Mouse) P21274, (Rat) P49001

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Entrez Gene ID: (Human) 650, (Mouse) 12156, (Rat) 29373

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功能