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Invitrogen
CD24 Monoclonal Antibody (SN3), Biotin
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CD24 Antibody (MA562261) in Flow
Flow cytometry (surface staining) of CD24 in human peripheral whole blood. Samples were stained with CD24 monoclonal antibody (Product # MA562261) using a dilution of 5 µg/mL. Separation of human neutrophil granulocytes (red-filled) from CD24 negative lymphocytes (black-dashed).
产品信息
MA562261
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
SN3
抗原
Glycoproteins purified from human NALM-1 cell line.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD24 is thought to play a role in regulating B-cell proliferation and maturation, as well as in controlling autoimmunity. Additionally, CD24 has been reported to interact with P-selectin (CD62P), indicating a potential role in cell adhesion and signaling. CD24 is a valuable marker for studying B-cell development, leukemia, lymphoma, and autoimmune regulation, as well as its interactions with other molecules like P-selectin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); FLJ22950; FLJ43543; MGC75043; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen
基因别名: CD24; CD24A
UniProt ID: (Human) R4I4T5
Entrez Gene ID: (Human) 100133941
response to hypoxia
cell activation
regulation of cytokine-mediated signaling pathway
response to molecule of bacterial origin
immune response-regulating cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Wnt signaling pathway
single organismal cell-cell adhesion
cell migration
regulation of epithelial cell differentiation
T cell costimulation
B cell receptor transport into membrane raft
chemokine receptor transport out of membrane raft
negative regulation of transforming growth factor beta3 production
positive regulation of activated T cell proliferation
regulation of phosphorylation
cholesterol homeostasis
positive regulation of MAP kinase activity
regulation of MAPK cascade
response to estrogen
respiratory burst
positive regulation of protein tyrosine kinase activity
glomerular visceral epithelial cell differentiation
glomerular parietal epithelial cell differentiation
intrinsic apoptotic signaling pathway
positive regulation of nephron tubule epithelial cell differentiation
