Bethyl Laboratories

CD36 Recombinant Rabbit Monoclonal Antibody (BLR259L)

查看其他74个CD36抗体

问题与答案

问题与答案

问题与答案

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Immunogen image

CD36 Recombinant Rabbit Monoclonal Antibody (BLR259L)

Immunogen Image CD36 Recombinant Rabbit Monoclonal Antibody (BLR259L)

产品信息

A700-259

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫组化（石蜡） (IHC (P))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:100-1:500

-

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

BLR259L

抗原

Peptide representing a region between residue 275 and 325 of mouse Platelet glycoprotein 4 (aka CD36).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

purified

保存液

BBS, pH 8.2

内含物

0.09% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

靶标信息

CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cd36; CD36 antigen; fatty acid translocase; glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; platelet glycoprotein IV; SR-B3; unnamed protein product

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基因别名: FAT; GPIV; Scarb3

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Entrez Gene ID: (Mouse) 12491

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beta-amyloid binding low-density lipoprotein receptor activity scavenger receptor activity long-chain fatty acid transporter activity protein binding high-density lipoprotein particle binding lipid binding short-chain fatty acid uptake transporter activity low-density lipoprotein particle binding Toll-like receptor binding signaling receptor activity cargo receptor activity macromolecular complex binding transforming growth factor beta binding thrombospondin receptor activity oleic acid binding lipoteichoic acid receptor activity lipoprotein particle binding oxidised low-density lipoprotein particle receptor activity oleate transmembrane transporter activity

negative regulation of transcription from RNA polymerase II promoter long-chain fatty acid metabolic process positive regulation of cytokine production positive regulation of cell-matrix adhesion negative regulation of systemic arterial blood pressure fatty acid metabolic process triglyceride metabolic process lipid transport receptor-mediated endocytosis phagocytosis, recognition inflammatory response cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration response to mechanical stimulus response to bacterium positive regulation of gene expression negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol storage fatty acid transport long-chain fatty acid transport plasma membrane long-chain fatty acid transport short-chain fatty acid transport negative regulation of angiogenesis fatty acid oxidation lipid storage positive regulation of blood coagulation intestinal cholesterol absorption cholesterol transport receptor internalization positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production response to lipid regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor 4 signaling pathway triglyceride transport chylomicron assembly plasma lipoprotein particle clearance low-density lipoprotein particle clearance cellular response to oxidative stress response to stilbenoid nitric oxide-cGMP-mediated signaling pathway negative regulation of protein import into nucleus eating behavior lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly apoptotic cell clearance positive regulation of MAPK cascade positive regulation of skeletal muscle tissue regeneration long-chain fatty acid import positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of angiogenesis positive regulation of phagocytosis defense response to Gram-positive bacterium intestinal absorption sensory perception of taste low-density lipoprotein particle mediated signaling positive regulation of phagocytosis, engulfment positive regulation of macrophage cytokine production positive regulation of stress-activated protein kinase signaling cascade positive regulation of ERK1 and ERK2 cascade cholesterol import response to fatty acid response to linoleic acid cellular response to bacterial lipopeptide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to low-density lipoprotein particle stimulus cellular response to hydroperoxide cellular response to diacyl bacterial lipopeptide positive regulation of triglyceride metabolic process energy homeostasis cell-cell adhesion regulation of action potential positive regulation of cold-induced thermogenesis cellular response to oxidised low-density lipoprotein particle stimulus oxidised low-density lipoprotein particle clearance amyloid-beta clearance by cellular catabolic process positive regulation of NLRP3 inflammasome complex assembly positive regulation of protein localization to plasma membrane positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid amyloid fibril formation lipid transport across blood brain barrier regulation of removal of superoxide radicals positive regulation of blood microparticle formation positive regulation of reactive oxygen species metabolic process