CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.
蛋白别名: Adhesion G protein-coupled receptor E5; Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta; CD97; CD97 antigen; EGF-TM7 receptor; Leukocyte antigen CD97
基因别名: AA409984; Adgre5; Cd97; TM7LN1
UniProt ID: (Mouse) Q9Z0M6
Entrez Gene ID: (Mouse) 26364
分子生物学功能: G-protein coupled receptor