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Invitrogen
CDK4/CDK6 Recombinant Rabbit Monoclonal Antibody (HL2323)
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CDK4/CDK6 Antibody (MA5-56640) in WB
Western Blot analysis of CDK4/CDK6 using CDK4/CDK6 Recombinant Monoclonal Antibody (Product # MA5-56640). Jurkat, Raji, and NCI-H929 whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with CDK4/CDK6 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-56640
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2323
抗原
Recombinant fragment of human CDK4 + CDK6.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
CDK4 (Cyclin-Dependent Kinase 4) and CDK6 (Cyclin-Dependent Kinase 6) are crucial regulators of the cell cycle, specifically involved in the transition from the G1 phase to the S phase. These kinases form complexes with D-type cyclins (Cyclin D1, D2, and D3), which are necessary for their activation. Once activated, CDK4 and CDK6 phosphorylate the retinoblastoma protein (RB1), leading to the release of E2F transcription factors that drive the expression of genes required for DNA synthesis and cell cycle progression. Dysregulation of CDK4 and CDK6 activity is a common feature in various cancers, as it can lead to uncontrolled cell proliferation. Consequently, CDK4 and CDK6 have become important targets in cancer therapy, with inhibitors such as palbociclib, ribociclib, and abemaciclib being developed and approved for the treatment of certain types of cancer, particularly hormone receptor-positive breast cancer. These inhibitors work by blocking the kinase activity of CDK4 and CDK6, thereby halting cell cycle progression and reducing tumor growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名:
Cell division protein kinase 4; Cell division protein kinase 6; CR2 protein kinase; CRK2; CRK3; cyclin dependent kinase 4; Cyclin-dependent kinase 4; Cyclin-dependent kinase 6; p34
基因别名: 5830411I20; AI504062; CDK4; CDK6; CDKN6; CMM3; Crk2; Crk3; MCPH12; PLSTIRE; PSK-J3
UniProt ID: (Human) P11802, (Human) Q00534, (Rat) P35426, (Mouse) P30285, (Mouse) Q64261
Entrez Gene ID: (Human) 1019, (Human) 1021, (Rat) 94201, (Mouse) 12567, (Rat) 114483, (Mouse) 12571
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
cyclin-dependent protein serine/threonine kinase regulator activity
cyclin binding
protein complex binding
protein kinase activity
kinase activity
nucleotide binding
protein serine/threonine kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
lens development in camera-type eye
protein phosphorylation
signal transduction
circadian rhythm
positive regulation of cell proliferation
response to toxic substance
response to lead ion
regulation of gene expression
positive regulation of G2/M transition of mitotic cell cycle
organ regeneration
response to testosterone
response to drug
positive regulation of apoptotic process
positive regulation of translation
positive regulation of cell cycle
positive regulation of cell size
regulation of protein kinase activity
positive regulation of fibroblast proliferation
cell division
response to hyperoxia
negative regulation of cell cycle arrest
positive regulation of cell-matrix adhesion
type B pancreatic cell development
cell cycle arrest
Notch signaling pathway
negative regulation of cell proliferation
response to virus
positive regulation of gene expression
astrocyte development
dentate gyrus development
lateral ventricle development
T cell differentiation in thymus
gliogenesis
cell dedifferentiation
negative regulation of cell differentiation
negative regulation of myeloid cell differentiation
regulation of erythrocyte differentiation
negative regulation of monocyte differentiation
negative regulation of osteoblast differentiation
negative regulation of cell cycle
generation of neurons
negative regulation of epithelial cell proliferation
hematopoietic stem cell differentiation
cellular response to phorbol 13-acetate 12-myristate
regulation of cell motility
negative regulation of cellular senescence
response to organic substance
regulation of cell proliferation
regulation of cell cycle
cell cycle
phosphorylation
hematopoietic progenitor cell differentiation
hemopoiesis
cell differentiation
