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Invitrogen
CEP290 Polyclonal Antibody
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图: 1 / 2
CEP290 Antibody (PA5-101506) in ICC/IF
Immunocytochemistry analysis of CEP290 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CEP290 polyclonal antibody (Product # PA5-101506) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-101506
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CEP290(Accession O15078), corresponding to amino acid residues S779-E829.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CEP290.
靶标信息
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bardet-Biedl syndrome 14 protein; Bardet-Biedl syndrome 14 protein homolog; Cancer/testis antigen 87; Centrosomal protein of 290 kDa; Cep290; CT87; Nephrocystin-6; Tumor antigen se2-2
基因别名: b2b1454Clo; b2b1752Clo; BBS14; BC004690; CEP290; KIAA0373; NPHP6
UniProt ID: (Mouse) Q6A078
Entrez Gene ID: (Mouse) 216274
transcription, DNA-templated
regulation of transcription, DNA-templated
transport
establishment or maintenance of cell polarity
protein transport
cell projection organization
regulation of cAMP metabolic process
nonmotile primary cilium assembly
cilium assembly
photoreceptor cell maintenance
positive regulation of transcription, DNA-templated
retina development in camera-type eye
cilium morphogenesis
regulation of establishment of protein localization
positive regulation of intracellular protein transport
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