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Invitrogen
CaMKII beta Monoclonal Antibody (CB-beta-1)
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CaMKII beta Antibody (13-9800) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), U-87MG (Lane 2) and PC12 (Lane 3). The blots were probed with Anti-CaM Kinase II beta Mouse Monoclonal Antibody (Product # 13-9800, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Secondary Antibody, HRP conjugate (Product # 62-6520, 1:4000 dilution). A 70 kDa band corresponding to CaM Kinase II beta was observed only in PC12. As it is a Rat immunogen, it did not react with human cell lines. Known quantity of pr... View More
产品信息
13-9800
应用
建议稀释比
已发表文章
产品规格
种属反应
Fish,
Human,
Mouse,
Sheep,
Rat,
Sea urchin
已发表种属
C. elegans,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
CB-beta-1
抗原
Purified rat brain CaM Kinase.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; CaMK II; caMK-II subunit beta; MGC29528; proline rich calmodulin-dependent protein kinase; β CaMKII; βCaMKII
基因别名: CAM2; CAMK2; CAMK2B; Camk2d; CAMKB; Ck2b
UniProt ID: (Human) Q13554, (Rat) P08413, (Mouse) P28652
Entrez Gene ID: (Human) 816, (Sheep) 101118870, (Rat) 24245, (Mouse) 12323
actin binding
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
protein kinase binding
protein homodimerization activity
phospholipase binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
protein phosphorylation
signal transduction
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
positive regulation of phospholipase A2 activity
positive regulation of GTPase activity
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
regulation of synapse structural plasticity
regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of cellular response to heat
G1/S transition of mitotic cell cycle
inhibitory G-protein coupled receptor phosphorylation
calcium ion transport
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
response to cadmium ion
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of apoptotic signaling pathway
nervous system development
phosphorylation
cell differentiation
