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Proteintech
Carboxypeptidase A1 Polyclonal Antibody
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产品信息
15836-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carboxypeptidase A1 Fusion Protein Ag8586 (71-419 aa encoded by BC005279)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is specific to CPA1.
Immunogen sequence: SIQAVKIFL ESHGISYETM IEDVQSLLDE EQEQMFAFRS RARSTDTFNY ATYHTLEEIY DFLDLLVAEN PHLVSKIQIG NTYEGRPIYV LKFSTGGSKR PAIWIDTGIH SREWVTQASG VWFAKKITQD YGQDAAFTAI LDTLDIFLEI VTNPDGFAFT HSTNRMWRKT RSHTAGSLCI GVDPNRNWDA GFGLSGASSN PCSETYRGKF ANSEVEVKSI VDFVKDHGNI KAFISIHSYS QLLMYPYGYK TEPVPDQDEL DQLSKAAVTA LASLYGTKFN YGSIIKAIYQ ASGSTIDWTY SQGIKYSFTF ELRDTGRYGF LLPASQIIPT AKETWLALLT IMEHTLNHPY (71-419 aa encoded by BC005279)
靶标信息
CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Carboxypeptidase A1; carboxypeptidase A1 (pancreatic); pancreatic carboxypeptidase A
基因别名: 0910001L12Rik; CPA; CPA1
UniProt ID: (Human) P15085, (Mouse) Q7TPZ8, (Rat) P00731
Entrez Gene ID: (Human) 1357, (Mouse) 109697, (Rat) 24269
