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产品信息
OMA1-06030
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Chicken,
Cat,
Goat,
Hamster,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat,
Xenopus,
Zebrafish
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
R2G
抗原
Total protein extract of chicken gizzard.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_325532
产品详细信息
OMA1-06030 detects cardiotin from mouse, rat, hamster, canine, monkey, pig, cat, rabbit, frog, goat, xenopus,feline and human cardiomyocytes.
OMA1-06030 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~300 kDa protein representing the cardiotin protein complex, as well as ~100 kDa and ~60 kDa bands representing the cardiotin subunits from rat heart extract.
The OMA1-06030 immunogen is total protein extract from chicken gizzard.
靶标信息
Cardiotin is a recently discovered, high molecular weight protein complex (~300 kDa) located in the longitudinal SR of cardiomyocytes. The cardiotin complex exists as 60 kDa and 100 kDa subunits. Both subunits contain the same amino-terminal 14 amino-acid sequence, and show high homology to human skeletal muscle alpha-actin. The tetrameric configuration of the cardiotin protein complex suggests that it exists as a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. Immunofluorescence studies colocalize cardiotin with SERCA 2a ATPase in the longitudinal sarcoplasmic reticulum (SR), although cardiotin is not expressed in junctional SR with SERCA 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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