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Invitrogen
Cullin 5 Polyclonal Antibody
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Cullin 5 Antibody (PA5-92425) in WB
Western blot analysis of Cullin 5 in rat heart. Samples were incubated with Cullin 5 Polyclonal antibody (Product # PA5-92425) using a dilution of 1:2,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-92425
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CUL5 (NP_0034692)
偶联物
形式
Liquid
浓度
0.82 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLKE EEKRALRYLE TRRECNSVEA LMECCVNALV TSFKETILAE CQGMIKRNET EKLHLMFSLM; Positive Samples: 293T, PC-3, Mouse heart, Mouse gastrocnemius muscle
靶标信息
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CUL-5; Cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); VACM-1; Vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1
基因别名: CUL5; VACM-1; VACM1
UniProt ID: (Human) Q93034, (Rat) Q9JJ31
Entrez Gene ID: (Human) 8065, (Rat) 64624
G1/S transition of mitotic cell cycle
cell cycle arrest
cell proliferation
negative regulation of cell proliferation
viral process
ERBB2 signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
calcium ion transmembrane transport
intrinsic apoptotic signaling pathway
protein polyubiquitination
ubiquitin-dependent protein catabolic process
response to osmotic stress
G-protein coupled receptor signaling pathway
protein ubiquitination
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
regulation of cytosolic calcium ion concentration
