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Invitrogen
Cytokeratin 1 Polyclonal Antibody
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Cytokeratin 1 Antibody (PA5-88276) in WB
Western blot analysis of Cytokeratin 1 in extracts of various cell lines. Samples were incubated with Cytokeratin 1 Polyclonal antibody (Product # PA5-88276) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-88276
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human Cytokeratin 1 (Cytokeratin 1 (KRT1)) (NP_0061123)
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FLEQQNQVLQ TKWELLQQVD TSTRTHNLEP YFESFINNLR RRVDQLKSDQ SRLDSELKNM QDMVEDYRNK YEDEINKRTN AENEFVTIKK DVDGAYMTKV DLQAKLDNLQ QEIDFLTALY QAELSQMQTQ ISETNVILSM DNNRSLDLDS IIAEVKAQYE DIAQKSKAEA ESLYQSKYEE LQITAGRHGD SVRNSKIEIS ELNRVIQRLR SEIDNVKKQI SNLQQSISDA EQRGENALKD AKNKLNDLED A; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane
靶标信息
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between approximately40 kDa and approximately68 kDa and isoelectric pH between 4. 9 - 7. 8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67 kDa cytokeratin; CK-1; Cytokeratin-1; K1; keratin 86; keratin complex 2, basic, gene 1; Keratin, type II cytoskeletal 1; Keratin-1; krt1 {ECO:0000250|UniProtKB:P04264}; type II keratin Kb1; Type-II keratin Kb1
基因别名: Kb1; Krt-2.1; Krt1; Krt2-1; Krt86
UniProt ID: (Mouse) P04104, (Rat) Q6IMF3
Entrez Gene ID: (Mouse) 16678, (Rat) 300250
