Immunogen sequence: RKRSHHGLGF LCCFGGSDIP EINLRDNHPL QFMEFSSPIP NAEELNIRFA ELVDEL
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.
DAAM2 is a recently identified planar cell polarity (PCP) signaling molecule implicated in the regulation of cellular polarity, convergent extension, and invasion. DAAM2 belongs to the formin homology family and contains a DAD (diaphanous autoregulatory) domain, an FH1 (formin homology 1) domain, an FH2 (formin homology 2) domain and a GBD/FH3 (Rho GTPase-binding/ formin homology 3) domain. The DAAM2 protein is known to be involved in cell divison. Though the exact function of DAAM2 is yet unknown, reports suggest that it is closely related to DAAM1 and hence along with DAAM1 it may also be required in Wnt/Fz signaling and activation of Rho and in regulating cytoskeleton architecture. DAAM2 is expressed in most of tissues but the expression level ishigher in brain.
蛋白别名: Disheveled-associated activator of morphogenesis 2; dishevelled-associated activator of morphogenesis 2; RP1-278E11.1
基因别名: DAAM2; dJ90A20A.1; KIAA0381
UniProt ID: (Human) Q86T65
Entrez Gene ID: (Human) 23500