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Peptide Sequence: FRGLKISAHG RSSSNVNGGP ELDRCISPEG VNGNRCSESS TLLEKYKIGK VIGDGNFAVV KECIDRSTGK EFALKIIDKA KCCGKEHLIE *
DCAMKL2 is a serine/threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CaMK-like CREB regulatory kinase 2; CL2; doublecortin and CaM kinase-like 2; Doublecortin domain-containing protein 3B; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; Serine/threonine-protein kinase DCLK2
基因别名: CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2
UniProt ID: (Human) Q8N568
Entrez Gene ID: (Human) 166614