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Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化 (IHC) |
1:2500-1:5000 | - |
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant protein corresponding to Human ESX1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.2 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2641131 |
Immunogen sequence: HEPEQQQEEP PLLELKQEQE EPPQTTVEGP QPAEGPQTAE GPQPPERKRR RRTAFTQFQ
Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 36%.
Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ESX1-related protein; Extraembryonic, spermatogenesis, homeobox 1; extraembryonic, spermatogenesis, homeobox 1 homolog; Homeobox protein ESX1; Homeobox protein ESX1-C; Homeobox protein ESX1-N; RP3-513M9.1
基因别名: ESX1; ESX1L; ESX1R; ESXR1
UniProt ID: (Human) Q8N693
Entrez Gene ID: (Human) 80712
分子生物学功能:
homeodomain transcription factor
