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Invitrogen
EpCAM Monoclonal Antibody (VU-1D9), Alexa Fluor™ 647
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA562295
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
VU-1D9
抗原
Small cell lung carcinoma cell line H69.
偶联物
Alexa Fluor™ 647
Alexa Fluor™ 647
Alexa Fluor™ 647
激发/发射光谱
650/671 nm
查看光谱
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenocarcinoma-associated antigen; adenocarcinoma-associated antigen precursor (KSA); cell surface glycoprotein Trop-1; epithelial glycoprotein (EGP) precursor; epithelial glycoprotein 314; hEGP314; human epithelial glycoprotein-2; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); TACSTD1; trophoblast cell surface antigen 1; tumor-associated calcium signal transducer 1; unnamed protein product
基因别名: Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314; EGP40; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1; MOC-31; TACSTD1; TROP1
UniProt ID: (Human) P16422
Entrez Gene ID: (Human) 4072
ureteric bud development
positive regulation of cell proliferation
signal transduction involved in regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
cell-cell adhesion
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of stem cell proliferation
Disclaimer
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