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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化 (IHC) |
1:20-1:50 | - |
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant protein corresponding to Human FAT4 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2641518 |
Immunogen sequence: FDDPDNIPPY GDDMTVRKQP EGNPKPDIIE RENPYLIYDE TDIPHNSETI PSAPLASPEQ EIEHYDIDNA SSIAPSDADI IQHYKQFRSH T
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cadherin family member 14; cadherin-related family member 11; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4; Protocadherin Fat 4; putative protein product of Nbla00548
基因别名: CDHF14; CDHR11; FAT-J; FAT4; FATJ; HKLLS2; NBLA00548; VMLDS2
UniProt ID: (Human) Q6V0I7
Entrez Gene ID: (Human) 79633
分子生物学功能:
cadherin
