Invitrogen

FOXO3A Polyclonal Antibody

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4 篇参考文献
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产品信息

720128

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-2 µg/mL
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免疫细胞化学 (ICC/IF)

1-2 µg/mL
-

染色质免疫沉淀 实验 (ChIP)

1-2 µg x 10^6 cells
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产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse, Xenopus

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide corresponding to Human FOXO3 (aa 29-37)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 0.1% BSA, 30% glycerol

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2610262

产品详细信息

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Goat, Pig, Bovine and Rabbit.

靶标信息

USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

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基因别名: 1110048B16Rik; 2010203A17Rik; AF6q21; C76856; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A

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UniProt ID: (Human) O43524, (Mouse) Q9WVH4

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Entrez Gene ID: (Human) 2309, (Mouse) 56484

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功能
core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding protein kinase binding chromatin DNA binding sequence-specific DNA binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation apoptotic process anatomical structure morphogenesis cell differentiation DNA damage response, signal transduction by p53 class mediator cellular response to oxidative stress glucose homeostasis positive regulation of neuron apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process tumor necrosis factor-mediated signaling pathway positive regulation of apoptotic process
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