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Invitrogen
FUS Monoclonal Antibody (CL0190)
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FUS Antibody (MA562968) in ICC/IF
Immunocytochemistry analysis of FUS was performed on U251 cell line. The cells were labeled with FUS Monoclonal Antibody (Product # MA562968) showing clear nuclear (without nucleoli) staining in green. Microtubule and nuclear probes are visualized in red and blue respectively.
产品信息
MA562968
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL0190
抗原
Recombinant protein corresponding to Human FUS
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
靶标信息
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 75 kDa DNA-pairing protein; fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; Oncogene FUS; Oncogene TLS; POMp75; RNA-binding protein FUS; Translocated in liposarcoma protein
基因别名: ALS6; ETM4; FUS; FUS1; HNRNPP2; POMP75; TLS
UniProt ID: (Human) P35637
Entrez Gene ID: (Human) 2521
nucleotide binding
DNA binding
transcription coactivator activity
RNA binding
protein binding
zinc ion binding
estrogen receptor binding
myosin V binding
ionotropic glutamate receptor binding
identical protein binding
poly(A) RNA binding
retinoid X receptor binding
thyroid hormone receptor binding
RNA metabolism protein
