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Immunogen sequence: MAQEFVNCK IQPGKVVVFI KPTCPYCRRA QEILSQLPIK QGLLEFVDIT ATNHTNEIQD YLQQLTGART VPRVFIGKDC IGGCSDLVSL QQSGELLTRL KQIGALQ (1-106 aa encoded by BC005304)
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: glutaredoxin (thioltransferase); glutaredoxin 1; glutaredoxin 1 (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; MGC117; MGC117407; thioltransferase; Thioltransferase 1; Thioltransferase-1; Thioltransferase1; TTase 1; TTase-1; TTase1
基因别名: C86710; D13Wsu156e; GLRX; Glrx1; GRX; GRX1; TTase
UniProt ID: (Human) P35754, (Mouse) Q9QUH0, (Rat) Q9ESH6
Entrez Gene ID: (Human) 2745, (Mouse) 93692, (Rat) 64045