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Alomone Labs, LTD
GPR143 Polyclonal Antibody
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GPR143 Antibody (AGR-083-200UL) in IHC (F)
Expression of GPR143 in mouse striatum. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Anti-GPR143 Antibody (#AGR-083) (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. GPR143 immunoreactivity (green) appears in the ventral striatum region (arrows). B. Pre-incubation of the antibody with GPR143 Blocking Peptide (BLP-GR083), suppressed staining. Cell nuclei are stain... View More
产品信息
AGR-083-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide RDKYEPAAVSEHGD, corresponding to amino acid residues 7- 20 of rat ATP1A1. Intracellular, N-terminus.
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: RDKYEPAAVSEHGD
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes. Defects in GPR143 are the cause of ocular albinism type 1 (OA1); also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein coupled receptor 143; homolog of human ocular albinism 1 (Nettleship-Falls); MOA1; ocular albinism 1; Ocular albinism type 1 protein; Ocular albinism type 1 protein homolog
基因别名: GPR143; NYS6; OA1; RGD1565799
UniProt ID: (Human) P51810, (Mouse) P70259
Entrez Gene ID: (Human) 4935, (Mouse) 18241, (Rat) 302619
eye pigment biosynthetic process
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
visual perception
melanosome localization
melanosome transport
melanosome organization
calcium-mediated signaling using intracellular calcium source
phosphatidylinositol-mediated signaling
regulation of calcium-mediated signaling
regulation of melanosome transport
regulation of melanosome organization
chemical synaptic transmission
