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Invitrogen
HBEGF Polyclonal Antibody
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HBEGF Antibody (PA5-48083) in WB
Western blot analysis of HBEGF in mouse spleen tissue. Samples were incubated in HBEGF polyclonal antibody (Product # PA5-48083) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Goat IgG secondary antibody. A specific band was detected for TREML4/TLT‚4 at approximately 55 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
PA5-48083
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse TREML4/TLT-4 Ser25-Val195
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) TREM1, rmTREM2b, and rmTREM3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: diphtheria toxin receptor; hb egf; heparin binding epidermal growth factor-like growth factor; Proheparin-binding EGF-like growth factor
基因别名: AW047313; Dtr; Dts; Hbegf; Hegfl
UniProt ID: (Mouse) Q06186
Entrez Gene ID: (Mouse) 15200
angiogenesis
blastocyst growth
epidermal growth factor receptor signaling pathway
regulation of heart contraction
cell migration
positive regulation of cell growth
positive regulation of cell migration
wound healing, spreading of epidermal cells
positive regulation of smooth muscle cell proliferation
negative regulation of elastin biosynthetic process
positive regulation of keratinocyte migration
positive regulation of protein kinase B signaling
positive regulation of wound healing
