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Invitrogen
HCN3 Monoclonal Antibody (TLL6C5)
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HCN3 Antibody (MA3-902) in IHC (P)
Immunohistochemistry was performed on cancer biopsies of deparaffinized Human colon carcinoma tissues. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:20 with a rat monoclo... View More
产品信息
MA3-902
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans,
Rat
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
TLL6C5
抗原
Synthetic peptide corresponding to residues T(640) L L A R S A R R S A G S P A S P L V P V R A G P L L A R G P W A S T S(675) of rat HCN3.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA3-902 detects HCN3 from human, mouse and rat samples.
MA3-902 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot MA3-902 detects a ~90 KDa band representing HCN3.
The MA3-902 immunogen is a synthetic peptide corresponding to residues T(640) L L A R S A R R S A G S P A S P L V P V R A G P L L A R G P W A S T S(675) of rat HCN3.
MA3-902 (clone TLL6C5) is a rat monoclonal hybridoma, produced by immunizing a rat, isolating the spleen cells, creating the hybridoma and successively injecting these cells into a mouse to produce ascites.
靶标信息
HCN3 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. HCN3 has been detected in the brain, but with less expression than other HCN channels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HAC-3; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Hyperpolarization-activated cation channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; MGC131493; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
基因别名: BCNG-4; Bcng4; Hac3; HCN3; Hcn4; KIAA1535
UniProt ID: (Human) Q9P1Z3, (Mouse) O88705, (Rat) Q9JKA8
Entrez Gene ID: (Human) 57657, (Mouse) 15168, (Rat) 114245
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cAMP binding
nucleotide binding
ion channel activity
intracellular cAMP activated cation channel activity
voltage-gated ion channel activity
potassium channel activity
sodium channel activity
protein binding
ion channel
transporter
kinase
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
regulation of postsynaptic membrane potential
cellular response to cAMP
potassium ion transmembrane transport
response to cisplatin
cellular response to dopamine
transport
ion transport
potassium ion transport
sodium ion transport
transmembrane transport
