Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:1,000 | - |
免疫细胞化学 (ICC/IF) |
1:100-1:500 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthetic peptide derived from the internal region of human HOXA11/D11 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2555801 |
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: homeo box 1I; homeo box 4F; homeo box A11; homeo box D11; Homeobox protein Hox-1.9; Homeobox protein Hox-1I; Homeobox protein Hox-4.6; Homeobox protein Hox-4F; Homeobox protein Hox-5.5; Homeobox protein Hox-A11; Homeobox protein Hox-D11; homeobox protein HOXA11; Hox-4.6, mouse, homolog of; HOX11
基因别名: E230017H14Rik; Hox-1.9; Hox-4.6; Hox-5.4; Hox-5.5; HOX1; HOX1I; HOX4; HOX4F; Hoxa-11; HOXA11; Hoxd-11; HOXD11; RUSAT1
UniProt ID: (Human) P31270, (Human) P31277, (Mouse) P31311, (Mouse) P23813
Entrez Gene ID: (Human) 3207, (Human) 3237, (Mouse) 15396, (Mouse) 15431
分子生物学功能:
homeodomain transcription factor
