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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属 |
Human |
表达系统 |
Insect |
氨基酸序列 |
Human ADAMTS1, amino acids Phe253-Asn616 with a C-terminal His-tag |
标签 |
His-tag |
分子量 |
41.017 kDa |
分类 |
Recombinant |
类型 |
Protein |
纯度 |
>90% by SDS-PAGE |
活性 |
Activity of ADAMTS1 is determined with recombinant aggrecan interglobular domain (Product # RP-77527). ADAMTS1 hydrolyzes the |
偶联物 |
Unconjugated |
形式 |
Liquid |
纯化类型 |
purified |
保存液 |
TBS, pH 7.5, with 5mM CaCl2, 0.05% Brij-35 |
内含物 |
no preservative |
保存条件 |
-80° C, Avoid Freeze/Thaw Cycles |
RP-77543 is a purified, truncated recombinant human ADAMTS1 protein expressed in insect cells.
RP-77543 may be used as a control with corresponding anti-ADAMTS1 antibodies. ADAMTS1 is inhibited by chelators of divalent cations such as EDTA and catechin gallate esters.
ADAMTS-1 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMs; ADAMTS-1; human metalloproteinase with thrombospondin type 1 motifs; metalloendopeptidases; METH-1
基因别名: ADAMTS1; C3-C5; KIAA1346; METH1
UniProt ID: (Human) Q9UHI8
Entrez Gene ID: (Human) 9510
分子生物学功能:
metalloprotease
