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Invitrogen

Human Activin A Recombinant Protein

查看其它 Human Activin A Protein货号
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产品信息

RP-75635

应用 建议稀释比 已发表文章

免疫印迹 (WB)

 Assay-dependent -

对照试剂 (Ctrl)

 Assay-dependent -
产品规格

种属

 Human

表达系统

 E. coli

氨基酸序列

 Human Activin A, amino acids 311-426 with an N-terminal His-tag

标签

 His-tag

分子量

 17.47 kDa

分类

 Recombinant

类型

 Protein

偶联物

 Unconjugated

形式

 Liquid

浓度

 0.05 mg/mL

纯化类型

 purified

保存液

 Laemmli, pH 6.8

内含物

 no preservative

保存条件

 -20° C, Avoid Freeze/Thaw Cycles

产品详细信息

RP-75635 contains a purified 116 amino acid fragment (aa311-426) corresponding to the mature Inhibin beta A chain protein with an N-terminal hexahistidine tag.

RP-75635 may be used as a positive control in Western blot assays.

靶标信息

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1

基因别名: EDF; FRP; INHBA

UniProt ID: (Human) P08476

Entrez Gene ID: (Human) 3624

分子生物学功能: growth factor

功能
G1/S transition of mitotic cell cycle ovarian follicle development hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter defense response cell cycle arrest cell surface receptor signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation male gonad development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation striatal medium spiny neuron differentiation cell differentiation erythrocyte differentiation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway endodermal cell differentiation growth negative regulation of phosphorylation odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion regulation of MAPK cascade negative regulation of interferon-gamma biosynthetic process negative regulation of B cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of follicle-stimulating hormone secretion positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion mesodermal cell differentiation cell development palate development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol GABAergic neuron differentiation extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
参与通路
cytokine activity transforming growth factor beta receptor binding hormone activity protein binding growth factor activity peptide hormone binding inhibin binding identical protein binding protein heterodimerization activity type II activin receptor binding

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