应用 | 建议稀释比 | 已发表文章 |
---|---|---|
对照试剂 (Ctrl) |
Assay-Dependent | - |
其他PubMed (Misc) |
- | 查看2篇已发表文章 2篇已发表文章 |
产品规格 | |
---|---|
种属 |
Human |
已发表种属 |
Not Applicable |
表达系统 |
E. coli |
氨基酸序列 |
Human IL-6 recombinant protein contains 184 amino acids |
分子量 |
20.9 kDa |
分类 |
Recombinant |
类型 |
Protein |
纯度 |
>97% |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4 |
内含物 |
no preservative |
保存条件 |
-20°C |
Description: Interleukin-6 is a potent lymphoid cell growth factor that affects B-lymphocytes, T-lymphocytes, and hybridoma cells. It will also affect cytotoxic T-cells in combination with other factors such as IL-2 and IFN-gamma. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
Purity: >97%.
Molecular Weight: 20.9 kDa.
Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; H-IL-6; Hybridoma growth factor; IFN-beta-2; IL-6; ILN; Interferon beta-2; Interleukin; interleukin BSF-2; Interleukin-6; Interleukin6; M-IL-6; R-IL-6
基因别名: BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6; IL6
UniProt ID: (Human) P05231
Entrez Gene ID: (Human) 3569