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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
Assay-dependent | - |
对照试剂 (Ctrl) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属 |
Human |
表达系统 |
E. coli |
氨基酸序列 |
Human VEGFR1 recombinant protein contains an N-terminal His-tag |
标签 |
His-tag |
分类 |
Recombinant |
类型 |
Protein |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.1 mg/mL |
纯化类型 |
purified |
保存液 |
0.025M acetic acid, pH 4.8, with 50% glycerol |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
This product contains purified recombinant human VeGF Receptor-1 protein with an N-terminal hexahistidine tag.
This product may be used as a positive control in many immunological assays.
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLT; FLT-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); i21; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGF R1; VEGFR-1
基因别名: FLT; FLT-1; FLT1; FRT; VEGFR-1; VEGFR1
UniProt ID: (Human) P17948
Entrez Gene ID: (Human) 2321
分子生物学功能:
transmembrane signal receptor
