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Invitrogen
IFNGR2 Polyclonal Antibody
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IFNGR2 Antibody (PA5-47089) in Neu
Neutralization of IFNGR2 in L‚929 mouse fibroblast cell line. Samples were incubated in IFNGR2 polyclonal antibody (Product # PA5-47089). Recombinant Mouse IFN‚γ reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the L‚929 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IFN‚γ (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti‚Mouse IFN‚γ R2 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 0.2-0.8 µ... View More
产品信息
PA5-47089
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse IFN- gamma R2 Ser21-Val243
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In Western blots, approximately 5% cross-reactivity with recombinant human IFN-gamma R2 is observed and less than 1% cross-reactivity with recombinant mouse (rm) IFN- gamma R1 and rmIFN-alpha / beta R2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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