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Abnova
INHA Polyclonal Antibody, MaxPab™
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产品信息
H00003623-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
INHA (ABM84699.1, 1 a.a. approximately 366 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT QHCACI
靶标信息
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A inhibin subunit; A-inhibin subunit; IHA; inhibin; Inhibin alpha chain
基因别名: INHA
UniProt ID: (Human) P05111
Entrez Gene ID: (Human) 3623
skeletal system development
ovarian follicle development
cell cycle arrest
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
nervous system development
male gonad development
response to external stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
erythrocyte differentiation
regulation of cell proliferation
negative regulation of phosphorylation
hemoglobin biosynthetic process
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of interferon-gamma biosynthetic process
negative regulation of B cell differentiation
negative regulation of macrophage differentiation
negative regulation of cell cycle
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
cell development
regulation of cell cycle
SMAD protein signal transduction
