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This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c; IQ motif and SEC7 domain-containing protein 2
基因别名: BRAG1; IQSEC2; KIAA0522; mKIAA0522; MRX1; MRX78; RGD1562109
UniProt ID: (Human) Q5JU85, (Mouse) Q5DU25
Entrez Gene ID: (Human) 23096, (Rat) 685244, (Mouse) 245666