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JMJD2B Antibody (712791) in ICC/IF
For immunofluorescence analysis, SK-OV-3 cells were fixed and permeabilized for detection of endogenous JMJD2B using Anti-JMJD2B Recombinant Rabbit Polyclonal Antibody (Product # 712791, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32731, 1:2000). Panel a) shows representative cells that were stained for detection and localization of JMJD2B protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (Produ... View More
产品信息
712791
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Polyclonal
类型
Antibody
克隆号
4HCLC
抗原
Protein corresponding to human JMJD2B [aa400-aa600]
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2848252
产品详细信息
This antibody is predicted to react with Mouse, Rat, Bovine
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(9) demethylase 4B; JmjC domain-containing histone demethylation protein 3B; jumonji domain containing 2B; Jumonji domain-containing protein 2B; lysine (K)-specific demethylase 4B; Lysine-specific demethylase 4B; tudor domain containing 14B
基因别名: JHDM3B; JMJD2B; KDM4B; KIAA0876; TDRD14B
UniProt ID: (Human) O94953
Entrez Gene ID: (Human) 23030
