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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Jumping translocation breakpoint protein; PAR protein; Prostate androgen-regulated protein; Protein JTB
基因别名: hJT; HJTB; HSPC222; JTB; PAR
UniProt ID: (Human) O76095, (Rat) O88823
Entrez Gene ID: (Human) 10899, (Rat) 29439
