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Invitrogen
KIFC2 Polyclonal Antibody
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产品信息
PA1-641
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: C S(780) G L T L E P P G D P P P(792)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-641 detects kinesin C2 (KIFC2) from mouse tissues.
PA1-641 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~100 kDa protein representing KIFC2 from mouse brain homogenate.
PA1-641 immunizing peptide corresponds to amino acid residues 780-792 from mouse KIFC2. PA1-641 immunizing peptide (Cat. # PEP-041) is available for use in neutralization and control experiments.
靶标信息
Kinesins are a superfamily of microtubule-associated motor proteins involved in a variety of cellular processes including membranous organelle transport and cell division. Kinesin has been found in a variety of organisms and cell types and is subject to spatial and temporal regulation. These proteins have a modular structure which includes a conserved motor domain of approximately 350 amino acids, which is responsible for microtubule binding and ATP hydrolysis. In addition to the motor domain, subfamily members share common domain organization, exhibit sequence similarity, motility properties, and cellular functions outside of the motor domain. An expansive phylogenetic tree of kinesins and kinesin-related proteins (KRPs) has been assembled based on this information. Kinesin C2 (KIFC2) is a C-type kinesin based on the position of the motor domain towards the carboxyl-terminus of the protein and is similar to members of the karyogamy protein 3 (KAR3) family involved in cell division. KIFC2 protein expression has been demonstrated in axons and dendrites of the central and peripheral nervous system. Unlike other C-type motor proteins, KIFC2 appears to play a role in retrograde axonal transport.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
