Bioss

KLF1, 2, 4 Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
技术支持

产品信息

BS-9526R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human KLF1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: EKLF; endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid transcription factor; erythroid-specific transcription factor EKLF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 1; Krueppel-like factor 2; Krueppel-like factor 4; Kruppel-like factor 1 (erythroid); Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor; monoclonal antibody A3D8; neonatal anemia; truncated EKLF; truncated erythroid Kruppel-like factor 1

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基因别名: CDAN4; EKLF; EZF; GKLF; HBFQTL6; INLU; KLF1; KLF2; KLF4; LKLF; Nan; Zie

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UniProt ID: (Human) Q13351, (Human) Q9Y5W3, (Human) O43474, (Mouse) Q60843, (Rat) Q9ET58, (Mouse) Q60793

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Entrez Gene ID: (Human) 10661, (Human) 10365, (Human) 9314, (Rat) 304666, (Mouse) 16596, (Mouse) 16598, (Rat) 306330, (Mouse) 16600, (Rat) 114505

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功能
core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding protein binding sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription cofactor binding beta-catenin binding zinc ion binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding protein domain specific binding activating transcription factor binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor binding C2H2 zinc finger transcription factor
参与通路
transcription, DNA-templated regulation of transcription, DNA-templated erythrocyte differentiation positive regulation of transcription, DNA-templated cellular response to peptide cell morphogenesis in utero embryonic development negative regulation of interleukin-6 production multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic erythrocyte maturation positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of protein metabolic process Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to cycloheximide cellular response to laminar fluid shear stress negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter mesodermal cell fate determination negative regulation of cell proliferation epidermal cell differentiation positive regulation of gene expression negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia stem cell population maintenance post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process negative regulation of heterotypic cell-cell adhesion somatic stem cell population maintenance post-embryonic hemopoiesis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of interleukin-8 biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis negative regulation of inflammatory response negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus negative regulation of cell migration involved in sprouting angiogenesis negative regulation of leukocyte adhesion to arterial endothelial cell negative regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of transcription regulatory region DNA binding liver development chromatin remodeling embryonic hemopoiesis erythrocyte development erythrocyte homeostasis response to laminar fluid shear stress cellular response to organic cyclic compound regulation of transcription from RNA polymerase II promoter response to organic substance cell differentiation response to retinoic acid regulation of cell proliferation
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